Coexistence of Anti-p200 Pemphigoid and Psoriasis: A Systematic Review
Coexistence of Anti-p200 Pemphigoid and Psoriasis: A Systematic Review
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BackgroundA close association between psoriasis and anti-p200 pemphigoid has been demonstrated by numerous studies.However, the clinical characteristics of patients suffering from these two entities have not yet been well-elucidated.ObjectiveThis study aimed to review the case reports and case series, summarizing clinical features and therapeutic strategies in patients suffering from anti-p200 pemphigoid and psoriasis.MethodsA systematic review was conducted by searching PubMed, EMBASE, and Web of Science databases for studies published in English involving patients with psoriasis and anti-p200 pemphigoid on 6 September 2021.
All case reports and case series reporting patients diagnosed with anti-p200 pemphigoid and psoriasis were included in this systematic review.ResultsA total tennessee titans dog bandana of 21 eligible studies comprising 26 anti-p200 pemphigoid patients with preceding psoriasis were included in the qualitative synthesis.The average age at blisters eruption was 62.5 years, and the mean duration between the two entities was 15.
6 years.Twenty-four percent of patients developed bullous lesions during UV therapy.Clinical manifestation of bullae and/or vesicles was recorded in all patients, and the trunk (94.7%) was most frequently involved, with only 15.
8% reporting mucosal involvement.Epitope spreading was detected by immunoblotting in 33.3% of patients.All the patients reached completed remission during the course of disease, with 36.
8% experiencing at least one relapse.Monotherapy of prednisolone was the leading therapeutic approach (n=6, 31.6%) required for disease control, but 5 (83.3%) of them suffered from blister recurrence after tapering or ceasing corticosteroid.
ConclusionMost of the clinical aspects of patients with anti-p200 pemphigoid and psoriasis were similar to what was demonstrated in previous articles on anti-p200 pemphigoid.Nevertheless, compared with other anti-p200 pemphigoid cases without psoriasis, a clinical manifestation pattern with more frequent involvement hydrangea red sensation of the trunk and less mucosal involvement was illustrated in those with psoriasis.Generally, monotherapy is sufficient for a complete remission for such patients.However, one or more relapses have been recorded in a considerable portion of patients, especially those prescribed with prednisolone.
It reminded us to be more cautious during a tapering of medication.